MLL (Mixed-linage leukemia or Myeloid-lymphoid leukemia) gene located at 11q23 was successfully cloned as early as 1991. The MLL gene is a key gene in the regulation of hematopoietic processes, and its abnormality is closely related to the pathogenesis of leukemia.
MLL gene 5’end region is labeled with an orange-red fluorescein and the 3’end labeled with a green fluorescein. The translocation of 11q23 region is detected with MLL gene break probe. All MLL gene rearrangements can be detected and avoiding separate detection due to missed diagnosis caused by gene fusion.
MLL gene can fuse with 51 genes after chromosomal translocation. The incidence of MLL gene changes in acute leukemia is about 5%-10%, but in infant ALL it is up to 79%, which is a sign of poor prognosis. EFS in 5 years is only 26.7%.
Product size: 100μL FISH probe ( ⬤ | ⬤ ) + Pretreatment reagent (10 tests) + Antifade staining solution DAPI (10 tests).