Biotech

Kit de sondas de detección del
cromosoma 12

Chromosome 12 probe detection kit

Trisomy 13 is the most common chromosome number abnormality in chronic lymphocytic leukemia (CLL), with an incidence of 40%-60%. It is often characterized by unique cytogenetic abnormalities. Among other genetic disorders, patients with trisomy 12 are considered to be at low risk.

Probe description

The centromere region of chromosome 12 is directly labeled with a green fluorescent dye.

Clinical significance  

Chromosome 12 trisomy is the most common chromosome number abnormality in B-CLL, with an abnormal proportion of more than 55%. The total survival time of trisomy 12 decreases and needs early treatment.

References

  • Swerdlow et al., editors, WHO Classification of Tumours of Haematopoietic and
  • Lymphoid Tissues, Lyon, France, IARC:2008
  • Puiggros et al., Biomed Res Int 2014;1-13
  • Rossi et al., Blood 2013;121(8):1403-1412

 

Product size: 100μL FISH probe ( ⬤ | ⬤ ) + Pretreatment reagent (10 tests) + Antifade staining solution DAPI (10 tests).