IGH separated dual-color probe aims to detect the translocation of 14q32.33 chromosome region (i.e., the IGH gene). IGH gene rearrangement is found in about 50% of NHLs (non-Hodgkin’s lymphoma), and also in T-ALL, CLL and ALL. Studies have shown that IGH gene translocation also occurs in children’s T-ALL.
5’end of IGH gene region is labeled with an orange-red fluorescein, and the 3’end labeled with a green fluorescein. The translocation of 14q32 region is detected with IGH gene break probe. All IGH gene rearrangements can be detected and avoiding separate detection due to missed diagnosis caused by gene fusion.
In ALL, the ratio of IGH to C-MYC translocation is the highest. In B-ALL and T-ALL, translocation of IGH with other genes is also more common.
Product size: 100μL FISH probe ( ⬤ | ⬤ ) + Pretreatment reagent (10 tests) + Antifade staining solution DAPI (10 tests).