ATM gene (ataxia telangiectasia mutated gene) is located at 11q22.3 and encodes a protein kinase involved in cell cycle regulation and activation of TP53 activity.
ATM gene deletion kit is a dual-color hybrid probe that directly labels ATM probe with an orange-red fluorescent dye. The probe specifically acts on the ATM gene at the chromosome 11q22.3 region, and the chromosome 11 centromere is directly labeled with a green fluorescent dye.
ATM gene deletion has a 15-20% incidence in B cell CLL, which is associated with disease invasiveness and poor prognosis. ATM gene deletion is the most common deletion abnormality in CLL, which can guide the selection of treatment options and prognosis evaluation.
Product size: 100μL FISH probe ( ⬤ | ⬤ ) + Pretreatment reagent (10 tests) + Antifade staining solution DAPI (10 tests).