Biotech

Kit de sondas de detección de
deleciones del gen RB1

RB1 deletion detection probe kit

    RB1 gene is located in the 13q14.2 region, its encoded protein acts as a tumor suppressor and plays a very important role in cell cycle and genomic DNA stability.

Probe description

RB1 gene deletion detection probe uses an orange-red fluorescent label RB1 gene, and the RB1 probe bind to the target detection site by in situ hybridization. This method is used to detect the abnormalities in multiple myeloma genes, and provide clinical reference for the differentiation, prognosis and medication for leukemia patients.

Clinical significance  

Some reseachers recommend MM differential diagnosis at the cytogenetic level. These changes are closely related to the prognosis of patients. Patients with RB1 gene deletion have a moderate prognosis with a median survival of 40 months.

References

  • Dal Bo M, et al. (2011) Genes Chromosomes Cancer 50: 633-43.
  • Di Fiore R, et al. (2013) J Cell Physiol 228: 1676-87.
  • Orlandi EM, et al. (2013) Hematol Oncol 31: 136-42.
  • Ouillette P, et al. (2011) Clin Cancer Res 17: 6778-90.

 

Product size: 100μL FISH probe ( ⬤ | ⬤ ) + Pretreatment reagent (10 tests) + Antifade staining solution DAPI (10 tests).