The MYC proto-oncogene is located on chromosome 8q24 and encodes a transcription factor that regulates cell growth. It is activated mainly by amplification and chromosome translocation rearrangement. MYC gene amplification is associated with the development of a variety of tumors (including breast cancer, colon cancer, lung cancer, hematopoietic tumors, etc.).
MYC gene amplification probe uses orange-red dye to label MYC gene region, and green dye to label chromosome 8 centromere region (CEP8). The MYC gene marker region is located at 8q24.21, and the CEP8 probe is labeled with a specific alpha satellite sequence.
MYC gene amplification is a common phenomenon in tumors and can be found in a variety of malignant tumors such as breast cancer, nasopharyngeal cancer, and cervical cancer. The prognosis of breast cancer patients with MYC gene amplification is poor.
Product size: 100μL FISH probe ( ⬤ | ⬤ ) + Pretreatment reagent (10 tests) + Antifade staining solution DAPI (10 tests).