Biotech

Kit de sondas de detección de
Deleción del gen 1p36 (SRD)

1p36 (SRD) gene deletion detection probe kit

Deletion of the 1p36 region (SRD gene) can occur in a variety of tumors, such as neuroblastoma, glioma, leukemia, lymphoma, and the like.

Probe description

1p36 (SRD) gene deletion probe uses an orange-red dye to label the SRD gene region, and a green dye to label chromosome 1 centromere region (CEP1). SRD gene marker region is located at 1p36, and the CEP1 probe is labeled with a specific alpha satellite sequence.

Clinical significance  

The deletion of 1p36 (SRD gene) in neuroblastoma is the most typical genetic alteration. The detection of 1p36 heterozygous deletion has a major significance in the clinical guidance and prognosis of neuroblastoma. 1p36 patients with neuroblastoma are prone to recurrence, have a poor prognosis, and are sensitive to chemotherapy.

References

  • Elsir T, et al. (2011) Br J Cancer 11: 1747-54.
  • Hoeller S, et al. (2012) Hum Pathol 43: 405-12.

 

Product size: 100μL FISH probe ( ⬤ | ⬤ ) + Pretreatment reagent (10 tests) + Antifade staining solution DAPI (10 tests).